曹春阳
基本情况
曹春阳，男，1970年8月 出生。中国科学院上海有机化学研究所“百人计划”研究员，课题组负责人。
学习与工作经历
1998年8月－2001年7月： 中国科学院上海有机化学研究所有机化学博士。
2001年8月－2004年1月： 美国约翰霍普金斯大学医学院药理系博士后。
2004年2月－2005年11月：美国约翰霍普金斯大学医学院药理系研究助理，核磁共振瓦里安谱仪500M与600M （配有低温探头）技术管理员。
2005年12月－2006年8月：美国加州膜蛋白结构研究中心Salk生物学研究所结构生物学实验室研究助理。
2006年9月－现在：中科院上海有机化学研究所“百人计划”研究员，课题组负责人。
主要研究方向与研究方法
1） 利用核磁共振（NMR）技术研究若干生物大分子溶液三维结构、动力学与功能关系。
2） 利用NMR研究许多重要酶在核酸复制过程中识别、剪切与修复核酸损伤位点的机制，以及相关蛋白与核酸相互作用机制。
3） 利用化学结构修饰（有机合成）与酶学方法研究与疾病相关的酶与底物相互作用机制。
4） 利用定点突变技术研究重要氨基酸及有关氨基酸侧链在酶生物催化过程中的作用。
5） 基于生物大分子溶液三维结构及相关酶生物催化机制, 利用有机合成方法进行抗肿瘤药物分子、其它药物分 子合理化设计。
发表文章列表
1) The Catalytic Power of Uracil DNA Glycosylase in the Opening of Thymine Base Pairs Chunyang Cao, Y.L. Jiang, Daniel Krosky, James T. Stivers Journal of the American Chemical Society, 2006, 128 (40), 13034-13035.
2) Dynamic opening of normal thymidine bases during enzymatic search for damaged sites in DNA Chunyang Cao, James T. Stivers Nature Structural and Molecular Biology 2004, 11(12), 1230-1236
3) Recognition of an Unnatural Difluorophenyl Nucleotide by Uracil DNA Glycosylase Y.L. Jiang; L. McDowell; D. Studelska; Chunyang Cao ; J. Schaefer, and James T. Stivers. Biochemistry, 2004, 43(49), 15429-15438.
4) Solution Structure of BmKK4, the First Member of Subfamily a-KTx 17 of Scorpion Toxins. Naixia, Zhang; Xiang, Chen; Minghua, Li; Chunyang, Cao; Yuefeng, Wang; Gong, Wu; Guoyuan, Hu; Houming, Wu, Biochemistry, 2004, 43, 12469-12476.
5) The merits of bipattite transition-state mimics for inhibition of uracil DNA glycosylase Yulin Jiang, Chunyang Cao, James T. Stivers, Fenhong Song, and Yoshi Ichikawa Bioorganic Chemistry 2004, 32 ( 4), 244-262.
6) The solution structure of the oxidized bovine microsomal cytochrome b5 mutant V45H Qi Zhang, Chunyang Cao, Houming Wu, Zhiqiang Wang, Yunhua Wang, Zhongxian Huang Protein Science 2004, 13(8), 2161-2169.
7) A novel zinc snap motif conveys structural stability to 3-methyladenine DNA glycosylase I. Keehwan Kwon, Chunyang Cao, and James T. Stivers The Journal of Biological Chemistry 2003, 278(23), 19442-19446.
8) Solution structure and base perturbation studies reveal a novel mode of alkylated base recognition by 3-methyladenine DNA glycosylase I Chunyang Cao, Keehwan Kwon, Yulin Jiang, Alexander Drohat, James T. Stivers The Journal of Biological Chemistry 2003, 278(48), 48012-48020.
9) The solution structure of the oxidized bovine microsomal cytochrome b5 mutant V61H; Chunyang Cao, Houming Wu, Linrong Xue, Yunhua Wang, Zhongxian Huang; Biochemical and Biophysical Research Communications, 2003, 307(3), 600-609.
10) Solution structure and biological activity of recombinant salmon calcitonin S-sulfonated analog. Yaofeng Wang, Dou Hong; Chunyang Cao, Zhang Naixia Mao Jifang; Jinbiao Ma, Houming Wu, Biochemical and Biophysical Research Communications 2003, 306(2), 582-9
11) NMR study of the effect on cytochrome b5 heme caused by the mutation in the residue Val45; Chunyang Cao, Yaofeng Wang, Houming Wu, Zhiqiang Wang, Yunhua Wang, Zhongxian Huang Biochimie 2003, 85(10), 1007-1016.
12) A large-scale progress for high purity taxol from bark extract of Taxus Yunnanesis; Xue Jun, Chunyang Cao, Jianmin Chen, Haishan Bu, Houming Wu; Chinese Journal of Chemistry, 2001,19(1), 82-90.
13) NMR Preliminary Study on cytochrome b5 mutant V45H; Chunyang Cao, Houming Wu, Zhiqiang Wang, Yunhua Wang, Zhongxian, Acta Chim. Sinica , 2000, 59(4), 578-586. (in Chinese)
14) Three-dimensional structure of Bmp03 from Venom of scorpion Buthus Martensii karscah; Fahu He, Yiming Li, Gong Wu, Chunyang Cao, Houming Wu, Acta Chimica Sinica, 2000, 58(7), 850-855. (in Chinese)
15) Synthesis and biological activities of substituted pyrazolo [4,5-e][1,3]thiazine derivatives. Jin, Guiyu; Chunyang Cao; Li, Lintao; Ren, Jun; Zhao, Guofeng. Nongyaoxue Xuebao 1999, 1(1), 15-19. (in Chinese)
16) Synthesis and biological activity of 1-aryl-4-substituted- pyrazolylcarbonylthio semicarbazides and related heterocyclic compounds. Jin, Gui-Yu; Hou, Zhen; Zhao, Guo-Feng; Chunyang Cao; Li, Yu-Chang. Gaodeng Xuexiao Huaxue Xuebao 1997, 18(3), 409-412. （in Chinese）
会议论文或论文摘要
17) NMR study of the effect on cytochrome heme caused by the mutation in the residue Pro40; Chunyang Cao, HouMing Wu, Yibing Tang, Wenxia Tang; Zhiqiang Wang, Yunhua Wang, Zhongxian Huang Abstracted invited paper the Proceedings of the 11th National Magnetic Resonance Conference of the CPS (Chinese Physical Society), 2000.
18) Uracil DNA Glycosylase Destabilizes Normal DNA Base Pairs Chunyang Cao, James T Stivers Abstracts of Papers, accepted in 228th ACS National Meeting, Phiadelphia, PA, United States, August 22-26, 2004