闫兵
闫兵博士，山东大学长江学者特聘教授，博士生导师，组合化学研究所所长。
１９８２年１月毕业于山东大学化学系，获学士学位。
１９８６年赴美国哥伦比亚大学化学系学习，师从著名生物有机化学家Koji Naknish教授，并于１９９０年获博士学位。
１９９０年至１９９３年先后师从英国剑桥大学/生理学研究所著名教授Peter A. McNaughton和美国休斯顿德克萨斯微生物和分子基因所世界著名教授John L. Spudich进行博士后研究工作。
１９９３年至１９９９年受聘于位于新泽西的Novartis Biomedical Research Institute。他负责创建的研究团队是美国最先投入组合化学研究的团队之一，最先建立了组合化学中应用于固相高通量合成技术中的分析和检测方法及反应动力学研究，推动了固相合成和组合化学的发展。
据不完全统计，闫兵博士在１９９６年发表在Journal of Organic Chemistry上该领域内的首创性论文被１４４次引用，他在该领域发表的7篇主要论文被引用次数迄今为止已超过６２５次。其研究成果很快得到了国际学术界的公认和好评，并被美国化学学会ACS出版发行的Chemical Engineering News（April６, １９９８）报道。
１９９８年，他和其他学术带头人在Anthony Czarnic博士的带领下为美国化学学会创刊发行了Journal of Combinatorial Chemistry（JCC），并担任两届编委至今。现任该杂志副主编。
１９９９年至２００５年，他受聘于美国Discovery Partners International和
Bristal-Myers Squibb，在组合化学中的合成、纯化和质量控制及用于早期药物开发的高通量筛选领域从事研究工作。
２００１年当选为Sigma Xi成员，并于２００２及２００４年应邀在匹兹堡会议上组织和主持了两次国际专题研讨会：PittCon 2002和PittCon 2004。
于２００７年在FACSS会议上主持国际专题会议。
闫兵博士组织并主持国际学术会议６次，１７次应邀在国际学术会议上作大会报告或特约报告，在分析化学和组合化学分析领域撰写专著４部，主编著作４部，并发表了１１部书章节或综述文 章，在Nature, Proc.Natl.Acad.Sci.USA, Curr.Opin.Chem.Biol., Acc. Chem.Res., Biochemistry, Biophys. J., Nano Lett., J.Med.Chem., Anal.Chem., J. Biol.Chem.和J.Comb.Chem.等杂志上发表论文７４篇，发表论文被他人引用超过１５３０次。
【研究领域和兴趣】
We use modern discovery tools such as combinatorial chemistry, high-throughput screening, computation and biological techniques to study some fundamental problems and processes in biology and medicine. Our research directions are two fold: the first is to modulate biological specificities of nanomaterials by controlling their surface chemistry to study their surface structure-activity and structure-toxicity relationships and discover biocompatible and cancer targeting nanomedicine and nanodiagnostics; the second is to develop anti-cancer chemical agents that target drug resistant cancers or molecular probes to understand biological processes. The drug development is a very long process. Our focus is to discover and optimize lead compounds, study the mechanism of action, and complete preclinical research for top candidates. We also develop various drug discovery and analytical chemistry technologies to assist our research goals and train graduate students (M.S. and Ph.D.) and postdoctoral fellows.
【主要论著】
1. Mu, Q.X., Li, Z.W., Li, X., Mishra, M.R., Zhang, B., Si, Z.K., Yang, L., Jiang, W., Yan, B.* (2009) Characterization of Protein Clusters of Diverse Magnetic Nanoparticles and Their Dynamic Interactions with Human Cells.J Phys ChemC (In press).New!
2. Ma, X.F., Shi, R.R., Zhang, B., Yan, B.* (2009) Kinetics of Resin-Supported Mitsunobu Esterification and Etherification Reactions.J Comb Chem(In press).New!
3. Du, F.F., Zhou, H.Y., Chen, L.X., Zhang, B., Yan, B.* (2009) Structure Elucidation of Nanoparticle-Bound Organic Molecules by H NMR.Trends in Analytical Chemistry28(1), 88-95.New!
4. Zhou, H.Y., Du, F.F., Li, X., Zhang, B., Li, W., Yan, B.* (2008) Characterization of Organic Molecules Attached to Gold Nanoparticle Surface Using High Resolution Magic Angle Spinning H NMR.J Phys ChemC 112(49), 19360-19366.New!
5. Yu, Y.M., Zhang, Q., Mu, Q.X., Zhang, B., Yan, B.* (2008) Exploring the Immunotoxicity of Carbon Nanotubes.Nanoscale Research Letters3(8), 271-277.New!
6. Lemoff. A and Yan, B.* (2008) Dual Detection Approach to a More Accurate Measure of Relative Purity in High-Throughput Characterization of Compound Collections.J Comb Chem10(5), 746-751.New!
7. Zhou, H.Y., Mu, Q.X., Gao, N.N., Liu, A.F., Xing, X.Y., Gao, S.L., Zhang, Q., Qu, G.B., Chen, Y.Y., Liu, G., Zhang, B., Yan, B. (2008) A Nano-Combinatorial Library Strategy for the Discovery of Nanotubes with Reduced Protein-Binding, Cytotoxicity, and Immune Response.Nano Letters8(3), 859-865.New!
8. Qi, M.H., Zhou, H.Y., Ma, X.F., Zhang, B., Jefferies, C., Yan, B. (2008) Feasibility of a Self-Calibrated LC/MS/UV Method to Determine the Absolute Amount of Compounds in Their Storage and Screening Lifecycle.J Comb Chem10(2), 162-165.
9. Mu, Q.X., Liu, W., Xing, Y.H., Zhou, H.Y., Li, Z.W., Zhang, Y., Ji, L.H., Wang, F., Si, Z.K., Zhang, B., Yan, B. (2008) Protein Binding by Functionalized Multiwalled Carbon Nanotubes Is Governed by the Surface Chemistry of Both Parties and the Nanotube Diameter.J Phys ChemC 112(9), 3300-3307.
10. Zhou, H.Y., Wu, S.H., Zhai, S.M., Liu, A.F., Sun, Y., Li, R.S., Zhang, Y., Ekins, S., Swaan, P.W., Fang, B.L., Zhang, B., Yan, B. (2008) Design, Synthesis, Cytoselective Toxicity, Structure-Activity Relationships, and Pharmacophore of Thiazolidinone Derivatives Targeting Drug-Resistant Lung Cancer Cell.J Med Chem51(5), 1242-1251.
11. Zhou, H., Liu, A., Li, X., Ma, X., Feng, W., Zhang, W., Yan, B. (2008) Microwave-Assisted Fluorous Synthesis of 4-Aryl-Substituted Thiazolidinone and Thiazinanone Libraries.J Comb Chem10(2), 303-312.Hot! (One of the Most Accessed Article 2008 from ACS Publications)
12. Zhang, B., Li, X.F., Yan, B. (2008) Advances in HPLC Detector-Towards Universal Detection.Anal Bioanal Chem390(1), 299-301.
13. Yu, Z.Y., Wang, F., Milacic, V., Li, X.F, Cui, Q.C, Zhang, B., Yan, B., Dou, Q.P. (2007) Evaluation of Copper-Dependent Proteasome-Inhibitory and Apoptosis-Inducing Activities of Novel Pyrrolidine Dithiocarbamate Analogs.Int J Mol Med20(6), 919-925.
14. Xu, P., Qiu, J.H., Zhang, Y.N., Chen, J., Wang, P.G., Yan, B., Song, J., Xi, R.M., Deng, Z.X., Ma, C.Q. (2007) Efficient Whole-Cell Biocatalytic Synthesis of N-Acetyl-D-Neuraminic Acid.Advanced Synthesis & Catalysis349(10), 1614-1618.
15.Yan, B., Shi, R., Zhang, B., Kshirsagar, T. (2007) A Kinetic Study of Product Cleavage Reactions from the Solid Phase by a Biocompatible and Removable Cleaving Reagent, HCl.J Comb Chem9(4), 684-689.
16. Shi, R., Wang, F., Yan, B. (2007) Site-Site Isolation and Site-Site Interaction - Two Sides of the Same Coin.Int J Pept Res & Therapeutics13(1-2), 213-219.
17. Chen, D., Cui, Q.C., Yang, H., Barrea, R.A., Sarkar, F.H., Sheng, S., Yan, B., Reddy, G.P.V., Dou, Q.P. (2007) Cliquinol, a Therapeutic Agent for Alzheimer’s Disease, Has Proteasome-inhibitory, Apoptosis-inducing and Anti-tumor Activities in Human Prostate Cancer Cells and Xenografts.Cancer Res67(4), 1636-1644.
18. Yan, B., Zhao, J., Leopold, K., Zhang, B., Jiang, G. (2007) The Structure Dependent Response of Chemiluminescence Nitrogen Detector (CLND) for Organic Compounds with Adjacent Nitrogen Atoms Connected by a Single Bond.Anal Chem79 (2), 718-726.
19. Daniel, K.G., Chen, D., Yan, B., Dou, Q.P. (2007) Copper-Binding Compounds as Proteasome Inhibitors and Apoptosis Inducers in Human Cancer.Front Biosci12, 135-144.
20. Zhai, S., Liu, W., Yan, B. (2007) Recent Patents on Treatment of Severe Acute Respiratory Syndrome (SARS).Recent Patents on Anti-Infective Drug Discovery2(1), 1-10.
21. Chen, L., Choo, J., Yan, B. (2007) The Microfabricated Electrokinetic Pump: A Potential Promising Drug Delivery Technique.Expert Opin Drug Deliv4(2), 119-129.
22. Landis-Piwowar, K.R., Milacic, V., Chen, D., Yang, H., Zhao, Z.Y., Chan, T.H., Yan, B., Dou, Q.P. (2006) Discovering Novel Anticancer Drugs and Chemo-Sensitizers by Using the Proteasome as a Potential Target.Drug Resistance Update9, 263-273.
23. Wu, S., Guo, W., Teraishi, F., Pang, J., Kaluarachchi, K., Zhang, L., Davis, J., Dong, F., Yan, B., Fang, B. (2006) Anticancer Activity of 5-Benzylidene-2-Phenyllimino-1,3-Thiazolidin-4-one (BPT) Analogs.Med Chem2(6), 597-605.
24. Cheng, X., Yan, B., Gao, L., Tang, H., Fan, Y., Anderson, S. N., Affleck, R., Burns, D. (2005) Compound Transfer Efficiency from Polystyrene Surfaces-Application to Micro-Arrayed Compound Screening.J Biomolecular Screening10(4), 293-303.
25. Irving, M., Krueger, C. A., Wade, J. V., Hodges, J. C., Leopold, K., Chan, C., Shaqair, S., Shornikov, A., Stock, M., Collins, N., Yan, B. (2004) High-Throughput Purification of Combinatorial Libraries II: Automated Separation of Single Diastereomers from a 1920-Member 4-Amidopyrrolidinone Library.J Comb Chem6, 478-486.
26. Yan, B., Collins, N., Wheatley, J., Irving, M., Leopold, K., Chan, C., Shornikov, A., Fang, L., Lee, A., Stock, M., Zhao, J. (2004) High-Throughput Purification of Combinatorial Libraries I: A High-Throughput Purification System Using an Accelerated Retention Window Approach.J Comb Chem6, 255-261.