常琪

常琪 药学博士 博士生导师 副研究员

个人简历：

1. 1984 年毕业于西安医学院药学系，获理学学士学位。

2. 1984 年分配到中国医学科学院药用植物研究所。

3. 1998 年起在香港中文大学药学院学习，攻读博士学位

4. 2002 年获理学博士学位。

5. 2002-2004 年在香港中文大学理学院生物系进行博士后研究

6. 2004 年起在中国医学科学院药用植物研究所工作 任药物代谢研究室副主任。

研究方向： 中药化学、中药质量标准、中药药物代谢动力学

先后承担和参与了国家中医药管理局“七五”、“八五”科技攻关课题、国家新药基金和国家自然科学基金课题。对多种中草药, 包括葛根、山楂、罗汉果、乌头、沙棘、绞股蓝及茶等, 进行了化学成分和质量标准的研究; 并对葛根黄酮，山楂黄酮和茶多酚等天然药物进行了药物吸收和代谢动力学的研究。在国内外刊物上发表论文近40篇。

近期发表论文：

1. Chang Q, Zuo Z, Chow MSS and Ho WKK: Effect of storage temperature on phenolics stability in hawthorn fruits and a hawthorn drink. Food Chemistry (in press).

2. Chang Q., Zuo Z., Ho W. K. K. and Chow M.: Comparison of the Pharmacokinetics of hawthorn Phenolics in Extract versus in individual Pure Compound. Journal of Clinical Pharmacology 2005 (45):106-112.

3. Chang Q., Zuo Z., Ho W. K. K. and Chow M.: Difference in absorption and bioavailability of the two structurally similar flavonoid glycosides, hyperoside and isoquercitrin, in rats. European Journal of Pharmacokinetics and Biopharmaceutics 2005 59 (3):549-555。

4. Zhang L, Lin G, Chang Q and Zuo Z: Role of intestinal first-pass metabolism of baicalein in its absorption process. Pharmaceutical Research. 2005 22 (8)：1050-1058。

5. Chang Q and Wong Y. S.: Identification of Flavonoids in Hakmeitau Beans (Vigna sinensis) by High Performance Liquid Chromatography / Electrospray Mass Spectrometry (LC-ESI-MS). Journal of Agricultural and Food Chemistry 2004 (52): 6694-6699.

6. Xu J. Z., Yeung S. Y. Venus, Chang Q., Huang Y. and Chen Z. Y.: Comparison of antioxidant activity and bioavailability of tea epicatechins with their epimers. British Journal of Nnutrition 2004 (91): 873-881.

7. Yin OQ, Chang Q, Tomlinson B, Chow S: The effect of CYP2D6 genotype on the pharmacokinetics of lovastatin in Chinese subjects. Clinical Pharmacoloty and Therapeutics 2004 (75): 18.

8. Chang Q., Yin Q. P. and Chow M.: A new liquid chromatography-tandem mass spectrometry method for the determination of tranexamic acid in human plasma. Journal of Chromatography B: 2004 (805): 275-280.

9. Ho, W. K. K., Chen, Z. Y., Huang, Y., Zhang, Z. S., Chang, Q., Chow, M, Liu, Y., Tomlinson, B.: Cardiovascular protective effects of hawthorn. In Nutraceutical Beverages: chemistry, Nutrition, and Health Effects, ACS Symposium Series 2004 (871): 62-75.

10. Chang Q, Zuo Z and Chow MSS: Hawthorn. Journal of Clinical of Pharmacology 2002; 42:605-612.

11. Chang Q, Zhu M, Zuo Z, Chow MSS and Ho WKK: High-performance liquid chromatographic method for simultaneous determination of hawthorn active components in rat plasma. Journal of Chromatography B 2001; 760:227-235.

12. Zhang ZS, Chang Q, Zhu M, Huang Y, Ho WKK, Chen ZY: Characterisation of antioxidants present in hawthorn fruits. Journal of Nutritional Biochemistry 2001; 12:144-152.