全哲山
全哲山，男, 1961年3月生,1991年毕业于北京医科大学(现北京大学医学部)获硕士学位，2005年于韩国圆光大学校获得理学博士学位。现任延边大学药学院药物化学教研部主任，教授，博士生导师，吉林省突出贡献中青年专家，吉林省拔尖创新人才，吉林省重点学科药物化学学科带头人，国家自然科学基金同行评议专家，国外“Bioorg Med Chem ”、“Bioorg Med Chem Lett” 、“Eur J Med Chem”、”Arch Pharm”等期刊论文评审专家数据库成员。在国内外发表论文80多篇，其中在SCI收录的杂志上发表学术论40多篇，累计影响因子53。申请中国发明专利3项, 获延边大学十五期间科研工作一等奖，荣获2006年度吉林省科技进步三等奖。
【研究方向与兴趣】一直从事药物化学教学与科研工作，研究方向为先导化合物的寻找与结构优化，主讲《药物化学》、《药物合成反应》、《新药设计与开发》等课目。已指导18名硕士研究生获得硕士，1名获得博士学位。现有硕士研究生12人，博士研究生3人。
【承担的科研项目】
1. 吡唑烷酮类化合物的合成及抗癫痫作用研究，国家自然科学基金课题，2005-2007，项目负责人。
２．喹喔啉酮衍生物的合成及抗癫痫作用研究．国家自然科学基金课题，2008-2010，项目负责人
3. 二苯甲基哌嗪类衍生物的合成和抗癫痫作用及作用机制研究。国家自然科学基金课题，2009-2011，项目负责人
4. 抗癫痫新药三唑喹酮的研制，教育部重点项目，2007-2009，项目负责人
5. 三唑酮并喹啉类化合物的合成及抗癫痫作用研究，教育部留学回国启动项目，2008-2010，项目负责人
【获奖】
“吡唑烷酮类抗癫痫先导化合物的寻找与结构优化”，吉林省科技进步三等奖，2006年,项目负责人。
【申请专利】
1.用作抗癫痫药的1,2,4-三唑并[4,3-a]喹啉-1-酮衍生物及其可药用盐, 中国发明专利，申请号为200610016578.1，公开号为CN 1807419, 发明人： 全哲山，孙先宇，魏成喜
2.用作抗抑郁药的5-烷氧基-四唑并[1,5-a]喹啉酮衍生物及其可药用盐，申请号200910004690.7，发明人：全哲山，邓先清
3.用作抗癫痫药的6-（取代苯氧基）-四唑并[5,1-a]酞嗪衍生物及其可药用盐，申请号，20081065734.X，发明人： 全哲山，
【近年主要发表论文】
2009年
36. Ji-Yong Liu, Hai-Ling Yu, Zhe-Shan Quan, Xun Cui, Hu-Ri Piao. Synthesis and inotropic evaluation of 1-substituted-N-(4,5-dihydro-1-methyl-[1,2,4]triazolo[4,3-a]quinolin-7-yl)
piperidine-4-carboxamides.Bioorg Med Chem Lett, in press
35. Xian-Yu Sun, Li-Ping Guan, Lei Zhang, Cheng-Xi Wei, Hu-Ri Piao and Zhe-Shan Quan*. Design. Synthesis and Anticonvulsant Activity Evaluation of 7-Substituted-4H-[1,2,4]triazino[3,4-a]phthalazin-4-one Derivatives.J Brazil Chem Soc,2009, 20(4)
34. Li-Ping Guan, Dong-Hai Zhao, Zhe Jiang, Hu-Ri Piao, Zhe-Shan Quan*. Evaluation of anticonvulsant activity of QUAN-0806 in various murine experimental seizure modelsPharmazie，2009，64，248-251
32. Li-Ping Guan, Cheng-Xi Wei, Xian-Qing Deng, Xin Sui, Hu-Ri Piao, Zhe-Shan Quan *. Synthesis and anticonvulsant activity ofN-(2-hydroxyethyl) cinnamamide derivatives.
Eur J Med Chem, 2009, in press
31. Ting Ting Li, Ling Zhang, Zhe Shan Quan, Hai Bo Zhu, Hu Ri Piao. Synthesis and positive inotropic evaluation of 1-(benzylamino)-3-(4,5-di-hydro[1,2,4]trizaolo[4,3-a]quinolin-7-
yloxy)propan-2-ol derivatives.Chinese Chem Lett,2009, 20，175-177
30. Lei Zhang, Li-Ping Guan, Xian-Yu Sun, Kyu-Yun Chai and Zhe-Shan Quan* . Synthesis and Anticonvulsant activity Evaluation of 6-Alkoxy-[1,2,4] triazolo[3,4-a]phthalazines.
Chem Biol Drug Des.2009, 73, 313-319
29. Cheng-Xi Wei, Li-Ping Guan, Jing-Hao Jia, Kyu-Yun Chai, and Zhe-Shan Quan*. Synthesis of 2-Substituted-6-(4H-1,2,4-triazol-4-yl)benzo[d]oxazoles as Potential Anticonvulsant Agents.Arch PharmRes,2009, 32，23-31
28. Li-Ping Guan, Dong-Hai Zhao, Jing-Hui Xiu, Xin Sui, Hu-Ri Piao, Zhe-Shan Quan*. Synthesis and Anticonvulsant activity ofN-(2-hydroxyethyl) amide derivatives.Arch Pharm, 2009, 342, 34-40
26. Xue-Kun Liu, Xun Cui, Li Hong, Liang-Peng Sun, Zhe-Shan Quan, Hu-Ri Piao. Synthesis of 2-(4-substituted-methylpiperazin-1-yl)-N-(3,4-dihydro-3-oxo-2H-benzo[1,4]oxazin-7-yl)acetamides and their positive inotropic evaluation.Eur J Med Chem.2008, in press.
23. Xian-Yu Sun, Lei Zhang, Cheng-Xi Wei, Piao Huri, Quan Zheshan*.Synthesis of 8-Alkoxy-5,6-dihydro-[1,2,4] triazino[4,3-a]quinolin-1-ones With Anticonvulsant Activity, and Assessment of Their Acute Toxicity.Eur J Med Chem,2009, 44, 1265-1270
25. Li-Jun Guo, Cheng-Xi Wei, Jing-Hao Jia, Li-Ming Zhao, Zhe-Shan Quan*. Design, Synthesis of 5-alkoxy-[1,2,4]triazolo[4,3-a]quinoline derivatives with anticonvulsant activity.Eur J Med Chem,2009, 44, 954-958
24. Jing Chen, Xian-Yu Sun, Kyu-Yun Chai, Jin-Seok Lee Young-Ae Ha and Zhe-Shan Quan*, Synthesis and anticonvulsant evaluation of 3- Substituted -4- (4-hexyloxyphenyl)-4H-1,2,4-triazoles.Med Chem Res, 2009, 18, 49-58
2008年
23. Jing-Yuan Li, Xun Cui, Xue Kun Liu, Li Hong, Zhe-Shan Quan, Hu-Ri Piao. Synthesis and positive inotropic evaluation of 2-(4-(4-substituted benzyloxy)-3-methoxybenzyl)-1,4-diazepan-1-yl)-N-(4,5-dihydro-1-methyl[1,2,4]triazolo[4,3-a]quinolin-7-yl)-acetamides.Arch Pharm. 2008, 341, 794-799. 22. Chun-Bo Zhang, Xun Cui, Li Hong, Zhe-Shan Quan, Hu-Ri Piao. Synthesis and positive inotropic activity of N-(4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolin-7-yl)-2-(piperazin-1-yl)acetamide derivatives.Bioorg Med Chem Lett. 2008, 18, 4606-4609.
21. Li-Ping Guan, Qing-Hao Jin, Shou-Feng Wang, Fu-Nan Li, Zhe-Shan Quan*. Synthesis and Anticonvulsant Activity of 5-Phenyl[1,2,4]triazolo[4,3-a]quinolines.Arch Pharm, 2008, 341, 774-779
20. Li-Ping Guan, Guan-Rong Tian, Kyu-Yun Chai, Jin-Seok Lee, Mi-Sun Song and Zhe-Shan Quan*. Synthesis and anticonvulsant activity of 1-substituted-7-methoxy-1,2,4-triazolo [4, 3-a]quinoline.Turk J Chem,2008, 32，181-189
19. Xian-Yu Sun, Cheng-Xi Wei, Kyu-Yun Chai,Hu-Ri Piao and Zhe-Shan Quan*. Synthesis and anti-inflammatory activities of some novel 7-alkoxy-1-amino-4,5-dihydro-[1,2,4]triazole
[4,3-a]quinolines.Arch Pharm, 2008, 341, 288-293
18. Zhong-Tai Piao,Li-Ping Guan, Li-Ming Zhao, Hu-Ri Piao, Zhe-Shan Quan*. Synthesis of Novel 7-benzyl-amino-2H-benzo [1,4]oxazin-3(4H)-ones as Anticonvulsant Agents.Eur J Med Chem, 2008, 43, 1216-1221
2007年
17. Jing Chen, Xian-Yu Sun, Kyu-Yun Chai, Jin-Seok Lee, Mi-Sun Song and Zhe-Shan Quan. Synthesis and anticonvulsant evaluation of 4-(4-alkoxylphenyl)-3-ethyl-4H-1,2,4-triazoles as open-chain analogues of 7-alkoxyl-4,5-dihydro[1,2,4]triazolo[4,3-a]quinolines.Bioorg Med Chem. 2007, 15，6775
16. Li-Ping Guan, Qing-Hao Jin, Guan-Rong Tian, Kyu-Yun Chai, Zhe-Shan Quan*. Synthesis of some quinoline-2(1H)-one and [1,2,4]triazolo[4,3-a]quinoline derivatives as potent anticonvulsant.J Pharm Pharm Sci,2007,10，254-262
15. Cheng-Xi Wei, Fu-Nan Li, Long-Xuan Zhao, Li-Ming Zhao, Zhe-Shan Quan*. Synthesis of 2-substitu-ted-7-heptyloxy-4, 5-dihydro-[1,2,4] triazolo[4,3-a]quinolin-1(2H)-ones as Anticonvulsant Activity.Arch Pharm, 2007, 340，491
14. Cui Xiangshu, Guan Liping, Li Hailan, Piao Huri, Quan Zheshan*. Synthesis and anticonvulsant activity of 7-benzylamino-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolines*.Prog Nat Sci, 2007, 17, 1104
13. Jin Yun-Zhe,Guan Li-Ping, Zao Li-Ming,Piao Hu-Ri, Quan Zhe-Shan*. Synthesis and Anticonvulsant Activity of 7-Substituted-phenoxyl-4,5-dihydro[1, 2, 4]triazolo[4,3-a]quinolines and Quinoline-1(2H)-ones.Chinese J Org Chem,2007, 28（12）,1567-1572
2006年
12. Hong-Guang Jin, Xian-Yu Sun, Kyu-Yun Chai, Hu-Ri Piao and Zhe-Shan Quan. Anticonvulsant and toxicity evaluation of some 7-alkoxy-4,5-dihydro[1,2,4]triazolo[4,3-a]quinoline-1(2H)-ones.Bioorg Med Chem,2006, 14, 6868-6873
11. Xian-Yu Sun, Gao Li,Chang-Soo Jun,Kyu-Yun Chai, Hu-Ri Piao and Zhe-Shan Quan. Synthesis and Evaluation of Anticonvulsant Properties of 8-Alkoxyl-4,5- dihydro-[1,2,4]triazolo [4,3-a]quinoline-1-ones.Arch Pharm Res, 2006, 29, 1080-1085
10. Jun-Min Wang, Chang-Soo Jun, Kyu-Yun Chai, Kyung-Chell Kwak, Zhe-Shan Quan. Synthesis and anticonvulsant activity of 1-substituted benzyl-N-substituted-1,2,3-triazole-4-Formamides.Prog Nat Sci, 2006, 16, 925-929
2005年
9. Zhi-Feng Xie,Kyu-Yun Chai, Hu-Ri Piao, Kyung Chell Kwak and and Zhe-Shan Quan*. Synthesis and anticonvulsant activity of 7-alkyl-4,5-dihydro-[1,2,4]triazolo[4,3-a]quiolines.Bioorg Med Chem Lett, 2005, 15, 4803-4805.
8. Li-Ming Zhao, Hai-Shan Jin, Liang-Peng Sun, Zhe-Shan Quan*. Synthesis and evaluation of antiplatelet activity of trihydroxychalcone derivatives.Bioorg Med Chem Lett.2005,15,5027-5029
7. Cui Li-Jing, Xie Zhi-Feng, Hu-Ri Piao, Gao Li, Kyu-Yun Chai. Quan Zhe-Shan*. Synthesis and Anticonvulsant Activity of 1-Substituted-7-Benzyloxy-4,5-dihydro-[1,2,4]triazolo[4,3-a]
quinoline.Biol Pharm Bull, 2005, 28, 1216-1220
6. Guan Li-Ping, Ji-Xing Nan, Xue-Jun Jin, Qing-Hao Jin, Kyung-Chell Kwak, Kyu-yun Chai1 and Zhe-Shan Quan*. Protective Effects of Chalcone Derivants for Acute Liver Injury in Mice.Arch Pharm Res, 2005, 28, 81-86
5. Zhe-Shan Quan, Jun-Min Wang, Jun-Rae Rho, Kyung-Chell Kwak, Hee Cheol Kang
Chang-Soo Jun, and Kyu-Yun Chai. Synthesis of 6- alkyloxyl-3,4-dihydro-2(1H)-quinoliones and their Anticonvulsant Activities.Bull korea chem Sci, 2005, 26, 1757-1760
4 . Kyung-Chell Kwak, Woo-Yiel Lee, Quan Zhe-Shan, Young-Hang Lee, Young-Gab Yun, Gyu-Beum Kwak, Hun-Taeg Chung, Tae-Oh Kwon and Kyu-Yun Chai*. Aditiong reaction α,α -Difluoroiodomethyl Ketones to Alkenes with a Copper Catalyst.Bull korea chem Sci, 2005, 26, 97-102
2003-2004年
3. Zhe-Shan Quan *,Li-Ming Zhao, Fu-Nan Li, Hu-Ri Piao. Synthesis of 2,3-disubstituted-5-hydroxybenzofuran derivatives.Chinese J Org Chem,2004, 24, 1637－1639
2. Li-Ping Guan，Xiu-Mei Yin, Hong-Mei Quan, Zhe-Shan Quan *. Synthesis of hydroxylated chalcones and related derivatives.Chinese J Org Chem,2004, 24, 1274-1277
1. Zhe-Shan Quan *，Yutak Ozaki, Sang-Won Kiu, Hu-Ri Piao。A new synthesis method of 2,5-dialkyl-1,4-benzenediol derivatives.Chinese J Org Chem，2003, 23, 1299-1302