郑耀武
【基本信息】性 别 男 出生年月 1959年9月15日
职 称 博士生导师 学 院 生命科学学院
专 业 分子遗传学，细胞生物学
【个人情况综述】1990年获美国南卡罗莱纳大学博士学位。现任东北师范大学生命科学院教授。长期从事基因的克隆、基因的表达及基因的调节研究工作，完成了多个基因的克隆工作，建立了多种细胞模型、转基因动物模型，以及多个基因的定位敲除动物模型。先后在Nature, Science，PNAS，BLOOD，JBC等权威杂志上发表了多篇论文。1993年开始从事与心血管病有关的凝血蛋白酶（血栓素）受体的研究工作，在血栓素受体基因克隆、基因表达，以及利用转基因动物和最新的基因敲除技术在血管内皮细胞生长因子（VEGF）基因的功能等方面进行了大量的、深入的研究，并取得了一系列科研成果，在国际血栓素受体和血管内皮生长因子研究领域内占有重要学术地位。
【学习工作简历】1978 —1982山西大学生命科学院植物生理学学生，获得学士学位；
1985 —1990美国南卡罗莱纳大学生命科学系分子遗传学研究生，获得博士学位；
1990 —1993美国加州大学旧金山分校病理系，博士后；
1982 —1984山西大学生命科学院助教
1985 —1990美国南卡罗莱纳大学生命科学系，研究助教
1990 —1993美国加州大学旧金山分校 心血管研究所，专职助研究员
1993 —1996美国加州大学旧金山分校 心血管研究所，专职副研究员
2000 —2003美国加州大学旧金山分校 心血管研究所，专职研究员一级
2003 —2006美国加州大学旧金山分校心血管研究所，专职研究员二级
2006 —现在美国加州大学旧金山分校心血管研究所，专职研究员三级
2005 —现在东北师范大学生命科学院膜通道实验室，教授
【社会学术兼职】现任北美生物科技学会（SCBA)会员，华园科技学会会员(HYSTA)会员，美西医药协会(SAPA- West)会员，以及中国细胞生物学学会（CSCB）会员。
【教学工作】主要讲授课程：
本科：《细胞生物工程》
【主要科研方向】研究领域：分子生物学、细胞生物学、基因工程、心血管病学
研究方向：基因的克隆、基因的表达调控；细胞工程和基因工程；心血管病的相关基因
的功能研究
发表论文：
1.Pappu R,Schwab SR,Comelissen I,Pereira JP,Regard JB,Xu Y,Camerer E,Zheng YW,Huang Y,Cyster JG,Coughlin SR.
Promotion of Lymphocyte Egress into Blood and Lymph by Distinct Sources of Sphingosine-1-Phosphate.
Science. 2007 Mar 15； [Epub ahead of print]
2.DE Candia E, Pecci A, Ciabattoni G, DE Cristofaro R, Rutella S, Yao-Wu Z, Lazzareschi I, Landolfi R, Coughlin S, Balduini CL.
platelet responsiveness to thrombin and protease-activated receptors agonists in a novel case of gray platelet syndrome: correlation between the platelet defect and the alpha-granule content in the patient and four relatives.
J Thromb Heamost.2007 Mar；5(3):551-9. Epub 2006 Nov 1
3. Griffin CT*, Srinivasan Y*, Zheng YW, Huang W, Coughlin SR.
A role for thrombin receptor signaling in endothelial cells during embryonic development.
Science. 2001 Aug 31；293(5535):1666-70.
*Equal contributors
4.Sambrano GR*, Weiss EJ*, Zheng YW*, Huang W, Coughlin SR.
Role of thrombin signaling in platelets in haemostasis and thrombosis.
Nature. 2001 Sep 6；413(6851):74-8.
*Equal contributors
5. Nakanishi-Matsui M, Zheng YW, Sulciner DJ, Weiss EJ, Ludeman MJ, Coughlin SR.
PAR3 is a cofactor for PAR4 activation by thrombin.
Nature. 2000 Apr 6；404(6778):609-13.
6. Camerer E, Cornelissen I, Kataoka H, Duong DN, Zheng YW, Coughlin SR.
Roles of protease-activated receptors in a mouse model of endotoxemia.
Blood. 2006 Jan 24； [Epub ahead of print]
7. Ruppel KM, Willison D, Kataoka H, Wang A, Zheng YW, Cornelissen I, Yin L, Xu SM, Coughlin SR.
Essential role for Galpha13 in endothelial cells during embryonic development.
Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8281-6. Epub 2005 May 26.
8. Ludeman MJ, Zheng YW, Ishii K, Coughlin SR.
Regulated shedding of PAR1 N-terminal exodomain from endothelial cells.
J Biol Chem. 2004 Feb 24 [Epub ahead of print]
9.Kataoka H, Hamilton JR, McKemy DD, Camerer E, Zheng YW, Cheng A, Griffin C, Coughlin SR.
Protease-activated receptors 1 and 4 mediate thrombin signaling in endothelial cells.
Blood. 2003 Nov 1；102(9):3224-31. Epub 2003 Jul 17.
10. Camerer E, Kataoka H, Zheng YW, Kahn M, Lease K, Coughlin SR.
Genetic evidences that protease-activated receptors mediate factor Xa signaling in endothelial cells.
J Biol Chem. 2002 May 3；277(18):16081-7.
11. Cases S, Smith SJ, Zheng YW, Myers HM, Lear SR, Sande E, Novak S, Collins C, Welch CB, Lusis AJ, Erickson SK, Farese RV Jr.
Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis.
Proc Natl Acad Sci U S A. 1998 Oct 27；95(22):13018-23.
12. Cases S, Novak S, Zheng YW, Myers HM, Lear SR, Sande E, Welch CB, Lusis AJ, Spencer TA, Krause BR, Erickson SK, Farese RV Jr.
ACAT-2, a second mammalian acyl-CoA: cholesterol acyltran-sferase. Its cloning, expression, and characterization.
J Biol Chem. 1998 Oct 9；273(41):26755-64.
13. Kahn ML, Zheng YW, Huang W, Bigornia V, Zeng D, Moff S, Farese RV Jr, Tam C, Coughlin SR.
A dual thrombin receptor system for platelet activation.
Nature. 1998 Aug 13；394(6694):690-4.
14. Ishihara H, Connolly AJ, Zeng D, Kahn ML, Zheng YW, Timmons C, Tram T, Coughlin SR.
Protease-activated receptor 3 is a second thrombin receptor in humans.
Nature. 1997 Apr 3；386(6624):502-6.
15. Cases, S； Zheng, YW；Novak， S； et al.
Identification and cloning of two new mammalian ACAT gene family members
Circulation, 96 (8): 1264-1264 Suppl. S OCT 21 1997
16. Zheng YW, Felder MR.
Genetic mapping of a possible new alcohol dehydrogenase sequence to mouse chromosome 3 at the Adh-1/Adh-3 complex.
Biochem Genet. 1997 Apr；35(3-4):105-17.
17. Xie D, Narasimhan P, Zheng YW, Dewey MJ, Felder MR.
Ten kilobases of 5'-flanking region confers proper regulation of the mouse alcohol dehydrogenase-1 (Adh-1) gene in kidney and adrenal of transgenic mice.
Gene. 1996 Nov 28；181(1-2):173-8.
18. Ishii K, Gerszten R, Zheng YW, Welsh JB, Turck CW, Coughlin SR.
Determinants of thrombin receptor cleavage. Receptor domains involved, specificity, and role of the P3 aspartate.
J Biol Chem. 1995 Jul 7；270(27):16435-40.
19. Zheng YW, Riegler J, Wu J, Yen TS.
Novel short transcripts of hepatitis B virus X gene derived from intragenic promoter.
J Biol Chem. 1994 Sep 9；269(36):22593-8.
20Yen, Tsb; Zheng, Yw
Novel Small Transcripts Of The Hepatitis-B Virus X-Gene
Journal Of Cellular Biochemistry, 218-218 Suppl. 18c Feb 13 1994
21. Zheng YW, Yen TS.
Negative regulation of hepatitis B virus gene expression and replication by oxidative stress.
J Biol Chem. 1994 Mar 25；269(12):8857-62.
22. Zheng YW, Bey M, Liu H, Felder MR.
Molecular basis of the alcohol dehydrogenase-negative deer mouse. Evidence for deletion of the gene for class I enzyme and identification of a possible new enzyme class.
J Biol Chem. 1993 Nov 25；268(33):24933-9.
23. Ceci JD, Zheng YW, Felder MR.
Molecular analysis of mouse alcohol dehydrogenase: nucleotide sequence of the Adh-1 gene and genetic mapping of a related nucleotide sequence to chromosome 3.
Gene. 1987；59(2-3):171-82.