王朝百科
分享
 
 
 

高福

王朝百科·作者佚名  2010-01-05  
宽屏版  字体: |||超大  

简介高福 英文名 : George Fu Gao

博士( DPhil-Oxon )

所长,研究员,博士生导师,

科学院“百人计划”入选者

主要履历及经历1979-1983 年 山西农业大学 学士

1983-1986 年 北京农业大学 硕士

1986-1991 年 北京农业大学 助教 / 讲师

1991-1994 年 英国牛津大学 博士 ( DPhil-Oxon )(师从 David H L Bishop, Ernest A Gould )

1994 年(3个月) 加拿大 Calgary University 博士后(师从 Robert Bell )

1995-1998 年 英国牛津大学 博士后(师从 John I bell, Andrew J McMichael, Bent K Jakobsen )

1999-2001 年 美国哈佛大学 / 哈佛医学院 博士后(师从 Don C Wiley, Stephen C Harrison )(工作期间资助:英国 Wellcome Trust International Travelling Fellow )

2001-2004 年 英国牛津大学 讲师、博士生导师、 Group leader

2004 年 - 现在 中国科学院微生物研究所 所长、研究员、博士生导师

主要承担课题

1.科技部十五科技攻关项目

2.科学院百人计划项目

3.科学院院长基金

4.科学院知识创新方向性项目

5.科技部 973 项目首席科学家

6.北京市自然科学基金

主要研究内容1. T 细胞受体( TCR )及其共受体 CD8 在细胞免疫识别过程中与其配体 peptide-MHC (peptide-HLA) 之间的相互作用机制。

2. 囊膜病毒侵入机体细胞过程中,病毒囊膜蛋白与细胞受体之间的相互作用。

3. 流感病毒、 SARS 病毒、 HIV 病毒、各类肝炎病毒等编码之蛋白质与宿主细胞之间的相互作用。

4. 多糖(尤其是中药多糖组分)参与天然免疫的分子机制

5. 其它蛋白质与蛋白质之间的相互作用

主要兼职中国农业大学兼职教授

武汉大学客座教授

军事医学科学院“病原微生物生物安全国家重点实验室”学术委员会委员

亚洲生物资源中心联盟 副主席

《药物生物技术》杂志编委

中国生物工程学会常务副理事长

中华预防医学会理事

《中国病毒学》编委

首都医科大学传染病系学术委员会副主任

获得荣誉中国科学技术协会首届“青年科技奖”获得者( 1988 年)

北京市科学技术协会“青年优秀论文奖”获得者( 1988 年)

中国微生物学会“青年优秀论文奖” 获得者( 1989 年)

英国文化委员会与中国国家教育委员会“中英友好奖学金” 获得者( 1991 年)

英国 Wellcome Trust “International Travelling Fellow” (1998 年 )

国家自然科学基金委员会“海外青年学者合作研究基金”(杰出青年 B 类)获得者( 2002 年)

教育部“春晖计划”学术休假基金获得者( 2003 年)

中国科学院“百人计划”获得者( 2004 年)

973首席科学家( 2005年 )

国家自然科学基金委员会“杰出青年科学基金”(A类)( 2005年 )

专利1.CD8 as an inhibitor of the cellular immune system, PCT/GB 98/03235 (1997) (with Gerth, U.C., Sewell, A.K., Bell , J.I. and Jakobsen, B.K.).

2.Soluble T cell receptor, PCT/GB 9810759.2 (1998) (with Willcox B.E., Boulter, J.M., Bell , J.I and Jakobsen, B.K.).

3.Heat-shock protein gp96 and HBV peptide complex used for HBV-induced hepatic carcinoma, PCT/CN01/00295 (2000) (with Meng, S.-D. and Tien, P.).

4.Potent peptide inhibitors for SARS coronavirus, 2003, China application No. (with Tien, P., Zhu, J., Xiao, G. & Zheng, C.).

主要论文Zheng Fan, Yue Zhuo, Xinyu Tan, Zhi Zhou, Jiangang Yuan, Boqin Qiang, Jinghua Yan, Xiaozhong Peng, George F. Gao*, 2006, SARS-CoV nucleocapsid protein binds to hUbc9, a ubiquitin conjugating enzyme of the sumoylation system, Journal Medical Virology, 78:1365–1373

David K Cole*, Pierre J Rizhallah, Jonathan M Boulter, Malkit Sami, Anne-lise Vuidepot, Meir Glick, Feng Gao, John I Bell, Bent K Jakobsen*, George F Gao*, 2006, Computational design and crystal structure of an enhanced affinity mutant human CD8aa co-receptor, PROTEINS: Structure, Function, and Bioinformatics (in press).

Shibichakravarthy Kannan, Aaron Audet, Jessica Knittel, Saman Mullegama, George F.Gao and Min Wu, 2006, Src kinase Lyn is crucial for Pseudomonas aeruginosa internalization into lung cells. European journal of Immunology,36:1739-1752

Minghai Zhou, Dongping Xu, Xiaojuan Li, Hongtao Li, Ming Shan, Jiaren Tang, Min Wang, Fu-Sheng Wang, Xiaodong Zhu, Hua Tao, Wei He, Po Tien*, and George F Gao*,2006, Screening and Identification of Severe Acute Respiratory Syndrome-Associated Coronavirus-Specific CTL Epitopes, Journal of Immunology, (in press)

Jiaqi Tang*#, Changjun Wang#, Youjun Feng#, Weizhong Yang#, Huaidong Song#, Zhihai Chen#, Hongjie Yu#, Xiuzhen Pan, Xiaojun Zhou, Huaru Wang, Bo Wu, Haili Wang, Huamei Zhao, Ying Lin, Jianhua Yue, Zhenqiang Wu, Xiaowei He, Feng Gao, Abdul Hamid Khan, Jian Wang, Guo-Ping Zhao, Yu Wang*, Xiaoning Wang*, Zhu Chen, George F Gao*, 2006,Streptococcal toxic shock syndrome caused by Streptococcus suis serotype2. PLoS Medicine,3(5):668-676 (#shared the first author)

David K. Cole, Pierre J. Rizkallah, Feng Gao , Neil I. Watson, Jonathan M. Boulter, John I. Bell, Malkit Sami, George F. Gao * & Bent K. Jakobsen*.2006.Crystal structure of HLA-A*2402 complexed with a telomerase peptide. European Journal of Immunology. 36:170-179 PDF

Li X, Liu X, Sun F, Gao J, Zhou H, Gao GF , Bartlam M, Rao Z. Crystal structure of the N-terminal SH3 domain of mouse betaPIX, p21-activated kinase-interacting exchange factor. Biochemical and Biophysical Research Communications . 2006 Jan 6; 339(1):407-14 PDF

Jinhua Liu#, Haixia Xiao#, Fumin Lei#, Qingyu Zhu, Kun Qin, Xiaowei Zhang, Xinglin Zhang, Deming Zhao, Guihua Wang, Youjun Feng, Juncai Ma, Wenjun Liu, Jian Wang, George F. Gao*. 2005. Highly pathogenic H5N1 influenza virus infection in migratory birds. Science.309:1206 (paper, som) (#shared the first author)

Ling Ni, Linqing Zhao, Yuan Qian, Jieqing Zhu, Zhibo Jin, Yu Wai Chen, Po Tien*, George F Gao*, 2005, Design and characterization of human respiratory syncytial virus entry inhibitors. Antiviral Therapy. 10:833-840

Jieqing Zhu, Xiuli Jiang, Yueyong Liu, Po Tien, George F Gao.2005. Design and characterization of viral polypeptide inhibitors targeting Newcastle disease virus fusion. Journal of Molecular Biology.354:601-613

Ling Ni a,b, Linqing Zhao c, George F. Gao a, Yuan Qian c,*, Po Tien a,* 2005.The antibodies directed against N-terminal heptad-repeat peptide of hRSV fusion protein and its analog-5-Helix inhibit virus infection in vitro. Biochemical and Biophysical Research Communications 331:1358-1364 PDF

Ling Ni a,b, George F. Gao a,*, Po Tien a,* Rational design of highly potent HIV-1 fusion inhibitory proteins: Implication for developing antiviral therapeutics. Biochemical and Biophysical Research Communications 332:831-836 PDF

Zheng Zhang, Dongping Xu, Yonggang Li, Lei Jin, Ming Shi, Min Wang, Xianzhi Zhou, Hao Wu, George F. Gao, Fu-Sheng Wanga,* 2005. Longitudinal alteration of circulating dendritic cell subsets and its correlation with steroid treatment in patients with severe acute respiratory syndrome. Clinical Immunology 116(3):225-35. PDF

Fuliang Chu ,Zhiyong Lou, Bin Gao, John I. Bell, Zihe Rao and George F. Gao*,2005,Complex assembly, crystallization and preliminary X-ray crystallographic studies of rhesus macaque MHC Mamu-A*01 complexed with an immunodominant SIV-Gag nonapeptide. Acta Crystallographica Section F Structural Biology and Crystallization Communications F61: 614-616. PDF

Li,H., Zhou,M., Han,J., Zhu,X., Dong,T., Gao, G.F*, and Po Tien* , 2005, Generation of murine CTL by a hepatitis B virus-specific peptide and evaluation of the adjuvant effect of heat shock protein glycoprotein 96 and its terminal fragments. The Journal of Immunology Jan 1;174(1):195-204 PDF

Gao, G.F. 2005, Filling the hole: evidence of a small molecule binding to the fusion core pocket in human respiratory syncytial virus. Expert Opinion on Investigational Drugs 14(2): 195-197

Yuan, F., Lou, Z., Li, X., Chen, Y., John I. Bell, Rao, Z., Gao*, G.F. 2005,Refolding,crystallization and preliminary X-ray structural studies of the West Nile virus envelope(E) protein domain Ⅲ. Acta Crystallographica Section F Structural Biology and Crystallization Communications F61,421-423 PDF

Li, S., Zhu, J., Peng, Y., Cui, S., Wang, C., Gao*, G.F, Tien, P*. 2005, Characterization of BIV Env core: Implication for mechanism of BIV-mediated cell fusion. Biochemical and Biophysical Research Communications (BBRC) 329(2005) 603-609 PDF

David K. Cole, Pierre J. Rizkallah, Malkit Sami, Nikolai M. Lissin, Gao, G.F., John I. Bell, Jonathan M. BBoulter, Meir Glick, Anne-Lise Vuidepot, Bent K. Jakobsen and Gao*, G.F. Crystallization and preliminary X-ray structural studies of a high-affinity CD8ααco-receptor to pMHC. Acta Crystallographica Section F Structural Biology and Crystallization Communications F61 PDF

Ni, L., Zhu, J., Zhang, J., Yan, M., Gao*, G.F., Po Tien*. 2005, Design of recombinant protein-based SARS-CoV entry inhibitors targeting the heptad-repeat regions of the spike protein S2 domain. Biochemical and Biophysical Research Communications (BBRC) 330:39-45.

Wang, X., Bai, Y., Zhang, G., Zhao, J., Wang, M., Gao*, G.F. 2005, Structure and function study of paramyxovirus fusion protein heptad repeat peptides. Archives of Biochemistry and Biophysics(ABB) 436(2005)316-322

Xu,D.,Zhang,Z.,Jin,L.,Chu,F.,Mao,Y.,Wang,H.,Liu,M.,Wang,M.,Zhang,L., Gao, G.F. and Wang,F.S.2005,Persistent shedding of viable SARS-CoV in urine and stool of SARS patients during the convalescent phase. European Journal of Clinical Microbiology & Infectious Diseases 24:165-171

Xu, Y., Lou, Z., Liu, Y., Pang, H.., Tien, P., Gao, G.F. , & Rao*, Z., 2004 , Crystal structure of severe acute respiratory syndrome coronavirus spike protein fusion core. Journal of Biological Chemistry (JBC) 279(47):49414-9 PDF

Xu, Y., Liu, Y., Lou, Z., Qin, L., Li, X., Bai, Z., Tien, P., Gao*, G.F. & Rao*, Z., 2004, Structural basis for coronavirus-mediated virus membrane fusion: crystal structure of MHV spike protein fusion core, Journal of Biological Chemistry (JBC) 279 (29):30514-22. PDF

Cole, D.K. & Gao*, G.F. , 2004, CD8: Adhesion molecule, co-receptor and immuno-modulator (invited review), Cellular and Molecular Immunology 1 (2): 81-88.

Pang, H., Bartlam, M., Zeng, Q., Miyatake, H., Hisano, T., Miki, K., Wong, L-L, Gao, G.F. & Rao, Z., 2004, Crystal structure of human pirin: an iron binding nuclear protein and transcription cofactor. Journal of Biological Chemistry (JBC) 279 (2): 1491-1498. PDF

Xu, D., Zhang, Z., Chu , F., Li, Y., Jin, L., Zhang, L., Gao, G.F. & Wang, F.-S., 2004, Genetic variation of SARS coronavirus in Beijing hospital, Emerging Infectious Diseases 10 (5): 789-794. PDF

Gao, G.F. , 2004, Just folding back: Convergence of viral fusion mechanisms (Monitor), Drug Discovery Today 9: 288. PDF

Xu, Y., Zhu, J., Liu, Y., Lou, Z., Yuan, F., Liu, Y., Cole, D.K., Ni, L., Su, N., Qin, L., Li, X., Bai, Z., Bell, J.I., Pang, H., Tien, P., Gao*, G.F. & Rao*, Z., 2004, Characterization of the heptad repeat regions, HR1 and HR2, and design of a fusion core structure model of the spike protein from severe acute respiratory syndrome (SARS) coronavirus, Biochemistry 43(44):14064-71. PDF

Zhu, X., Li, C., Lang, Z., Gao*, G.F. & Tien*, P., 2004, Significant correlation between expression level of HSP gp96 and the progression of hepatitis B virus induced diseases, World Journal of Gastroenterology 10 (8): 1141-1145. PDF

Xu, Y., Cole, D.K., Lou, Z., Liu, Y., Qin, L., Li, X., Bai, Z., Yuan, F., Rao*, Z. & Gao*, G.F. , 2004 , Construct design, biophysical, and biochemical characterization of the fusion core from mouse hepatitis virus (a coronavirus) spike protein. Protein Expression and Purification 38(1):116-22. PDF

Xu, Y., Gao, S., Cole, D.K., Zhu, J., Su, N., Wang, H., Gao*, G.F. & Rao*, Z., 2004, Basis for fusion inhibition by peptides: analysis of the heptad repeat regions of the fusion proteins from Nipah and Hendra viruses, newly emergent zoonotic paramyxoviruses, Biochemical and Biophysical Research Communications (BBRC) 315 (3): 664-670 PDF

Zhu, J., Xiao, G., Xu, Y., Yuan, F., Zheng, C., Liu, Y., Cole, D.K., Yan, H., Bell, J.I., Rao, Z., Tien*, P. & Gao*, G.F. , 2004, Following the rule: formation of the 6-helix bundle of the fusion core from severe acute respiratory syndrome coronavirus (SARS-CoV) spike protein and identification of potent peptide inhibitors, Biochemical and Biophysical Research Communications (BBRC) 319: 283-288. PDF

Liu, Y., Zhu, J., Feng, M., Tien, P. & Gao*, G.F. , 2004, Six-helix bundle assembly and analysis of the central core of mumps virus fusion protein. Archives of Biochemistry and Biophysics (ABB) 421: 143-148. PDF

Yan, H., Xiao, G., Zhang, J., Hu, Y., Yuan, F., Cole, D.K., Zheng*, C. & Gao*, G.F. , 2004, SARS coronavirus induces apoptosis in Vero E6 cells, Journal of Medical Virology 73: 323-331. PDF

Xu, Y., Lou, Z., Liu, Y., Cole, D.K., Su, N., Qin, L., Li, X., Bai, Z., Rao, Z. & Gao*, G.F. , 2004, Crystallization and preliminary crystallographic analysis of the fusion core from two new zoonotic paramyxoviruses, Nipah virus and Hendra virus. Acta Crystallographica Section D Biological Crystallography D60: 1161-1164 .

Zhou, M., Xu, Y., Lou, Z., Cole, D.K., Li, X., Liu Y.,Tien, P., Rao*, Z. & Gao*, G.F. , 2004, complex assembly, crystallization and preliminary X-ray crystallographic studies of MHC H-2 k d complexed with an HBV core nonapeptide, Acta Crystallographica Section D Biological Crystallography 60(Pt 8):1473-5. PDF

Wang, X., Xu, Y., Cole, D.K., Lou, Z., Liu, Y., Rao, Z., Wang*, M. & Gao*, G.F. , 2004, Biochemical, biophysical and preliminary X-ray crystallographic analyses of the fusion core of Sendai virus F protein, Acta Crystallographica Section D Biological Crystallography 60(Pt 9):1632-5. PDF

Xu, Y., Bai, Z., Qin, L., Li, X., Gao*, G.F. & Rao*, Z., 2004, Crystallization and preliminary crystallographic analysis of the fusion core of the spike protein of the murine coronavirus mouse hepatitis virus (MHV). Acta Crystallographica Section D Biological Crystallography 60 (Pt 11):2013-5. PDF

Xu, Y., Su, N., Qin, L.,Bai, Z., Gao, G.F. , & Rao*, Z., 2004, Crystallization and preliminary crystallographic analysis of the heptad-repeat complex of SARS coronavirus spike protein. Acta Crystallographica Section D Biological Crystallography D60 (Pt 12 Pt 2):2377-9.

王晓佳,张卫红,汪明,高福, 2004 ,囊膜病毒膜融合的分子机制。 生物化学与生物物理进展 31 ( 6 ): 482-491 。

Yang, H., Yang, M., Ding, Y., Liu, Y., Lou, Z., Zhou, Z., Sun, L., Mo, L.,Ye, S., Pang, H., Gao, G.F. , Anand, K., Bartlam, M., Hilgenfeld, R. & Rao, Z., 2003, The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor. Proceedings of National Academy of Sciences USA (PNAS) 100 (23): 13190-13195. PDF

Ding, Y., Xu, G., Yang, M., Yao , M., Gao, G.F. , Wang, L., Zhang, W. & Rao, Z., 2003, Crystal structure of the ectodomain of human FcRI. Journal of Biological Chemistry (JBC) 278 (30): 27966-27970. (with front cover illustration). PDF

Wang, E., Sun, X., Qian Y., Zhao, L., Tien, P. & Gao* , G.F. , 2003, Both heptad repeats of human respiratory syncytial virus fusion protein are potent inhibitors of viral fusion. Biochemical and Biophysical Research Communications (BBRC) 302: 469-475. PDF

Zhu, J., Ding, Y., Gao, F., Wu, T., Zhang, C.W.-H., Tien, P., Rao, Z. & Gao* , G.F. , 2003, Crystallization and preliminary X-ray crystallographic analysis of the trimer core from measles virus fusion protein. Acta Crystallographica Section D Biological Crystallography D59: 587-590. PDF

Li, P., Zhu, J., Wu, B., Gao, F., Tien, P., Rao, Z. & Gao*, G.F. , 2003, Crystallization and preliminary X-ray diffraction analysis of post-fusion 6-helix bundle core structure from Newcastle disease virus F protein. Acta Crystallographica Section D Biological Crystallography D59: 1296-1298.

Zhu, J., Li, P., Wu, T., Gao, F., Ding Y., Zhang, C.W.-H., Rao, Z., Gao*, G.F. & Tien*, P., 2003, Design and analysis of post-fusion 6-helix bundle of heptad repeat regions from Newcastle disease virus F protein. Protein Engineering 16: 373-379. *Shared correspondence author PDF

Zhu, J., Zhang, C.W.-H., Rao, Z., Tien, P. & Gao*, G.F. , 2003, Biochemical and biophysical analysis of heptad repeat regions from the fusion protein of Menangle virus, a newly emergent paramyxovirus. Archives of Virology 148: 1301-1316. PDF

Gao,* G.F. , Rao, Z. & Bell, J.I., 2002, Molecular coordination of a b T-cell receptors and coreceptors CD8 and CD4 in their recognition of peptide-MHC ligands. Trends in Immunology 23: 408-413. *Correspondence author PDF

Gao, G.F ., 2002, CD8 a a and CD8 a b : truly different? (News and comment). Trends in Immunology 23: 177. PDF

Gao, G.F. & Rao, Z., 2002, Seeing the change: TCR binds pMHC with an ‘induced-fit' (News and comment). Trends in Immunology 23: 281. PDF

Rao, Z. & Gao, G.F. , 2002, Lipid-antigen presentation by CD1 is crystal clear (News and comment). Trends in Immunology 23: 473. PDF

Jiang, S., Borthwick , N.J. , Morrison, P., Gao, G.F. & Steward, M.W., 2002, Virus-specific CTL responses induced by an H-2Kd-restricted, motif-negative 15-mer peptide from the fusion protein of respiratory syncytial virus . Journal of General Virology 83: 429-438. PDF

Yu, M., Wang, E., Liu, Y., Cao, D., Jin, N., Zhang, C.W.-H, Bartlam, M., Rao, Z., Tien, P. & Gao*, G.F. , 2002, Six-helix bundle assembly and characterization of heptad repeat regions from the F protein of Newcastle disease virus . Journal of General Virology 83: 623-629. PDF

Zhu, J., Zhang, C.W.-H., Qi, Y., Tien, P. & Gao*, G.F. , 2002, The fusion protein core of measles virus forms stable coiled coil trimer. Biochemical and Biophysical Research Communications (BBRC) 299: 897-902. PDF

Meng, S.-D., Song, J., Rao, Z., Tien, P. & Gao*, G.F. , 2002, Three-step purification of gp96 from human liver tumor tissues suitable for isolation of gp96-bound peptides. Journal of Immunological Methods 264: 29-35. PDF

Meng, S.-D., Gao, T., Gao*, G.F. & Tien*, P., 2001, HBV-specific peptide associated with heat-shock protein gp96. The Lancet 357: 528-529. *Shared correspondence author PDF

Lin, C.-L., Sewell, A.K., Gao, G.F. , Whelan, K., Phillips, R.E. & Austyn, J.M., 2000, Macrophage-tropic HIV induces and exploits dendritic cell chemotaxis. Journal of Experimental Medicine 192: 587-593. PDF

Gao, G.F. , Willcox, B.E., Wyer, J.R., Boulter, J.M., O'Callaghan, C.A., Maenaka, K., Stuart, D.I., Jones, E.Y., van der Merwe, P.A., Bell, J.I. & Jakobsen, B.K., 2000, Classical and nonclassical class I major histocompatibility complex molecules exhibit subtle conformational differences that affect binding to CD8αα Journal of Biological Chemistry (JBC) 275: 15232-15238. PDF

Gao,* G.F. & Jakobsen, B.K., 2000, Molecular interactions of coreceptor CD8 and MHC class I: the molecular basis for functional coordination with the T-cell receptor. Immunology Today 21 (12): 630-636. *Correspondence author PDF

Sewell, A.K., Gerth, U.C., Price, D.A., Purbhoo, M.A., Boulter, J.M., Gao, G.F. , Bell, J.I., Phillips, R.E. & Jakobsen, B.K., 1999, Antagonism of cytotoxic T-lymphocyte activation by soluble CD8. Nature Medicine 5: 399-404. PDF

Wyer* J.R., Willcox*, B.E., Gao*, G.F. , Gerth, U.C., Davis, S.J., Bell, J.I., van der Merwe, P.A. & Jakobsen, B.K., 1999, T cell receptor and coreceptor CD8 a a bind peptide-MHC independently and with distinct kinetics. Immunity 10: 219-225. *Shared first author PDF

McGuire, K., Holmes, E.C., Gao, G.F. , Reid, H.W. & Gould, E.A., 1998, Tracing the origins of louping ill virus by molecular phylogenetic analysis. Journal of General Virology 79: 981-988.

Gao, G.F. , Gerth, U.C., Wyer, J.R., Willcox, B.E., O'Callaghan, C.A., Zhang, Z.H., Jones, E.Y., Bell, J.I. & Jakobsen, B.K., 1998, Assembly and crystallization of the complex between the human T cell coreceptor CD8 a homodimer and HLA-A2. Protein Science 7: 1245-1249. PDF

Willcox*, B.E., Gao*, G.F. , Wyer, J.R., Ladbury, J.E., Bell, J.I., Jakobsen, B.K. & van der Merwe, P.A., 1999, TCR binding to peptide-MHC stabilizes a flexible recognition interface. Immunity 10: 357-365. *Shared first author PDF

Maenaka, K., Juji, T., Nakayama, T., Wyer, J.R., Gao, G.F. , Maenaka, T., Zaccai, N.R., Kikuchi, A., Yabe, T., Tokunaga, K., Tadokoro, K., Stuart, D.I., Jones, E.Y. & van der Merwe, P.A., 1999, Killer cell immunoglobulin receptors and T cell receptors bind peptide-Major Histocompatibility Complex class I with distinct thermodynamic and kinetic properties. Journal of Biological Chemistry (JBC) 274: 28329-28334. PDF

Willcox*, B.E., Gao*, G.F. , Wyer, J.R., O'Callaghan, C.A., Jones, E.Y., van der Merwe, P.A., Bell, J.I. & Jakobsen, B.K., 1999, Production of soluble a b T-cell receptor heterodimers suitable for biophysical analysis of ligand binding. Protein Science 8: 2418-2423. *Shared first author PDF

Gao, G.F. , Tormo, J., Gerth, U.C., Wyer, J.R., McMichael, A.J., Stuart, D.I., Bell, J.I., Jones, E.Y. & Jakobsen, B.K., 1997, Crystal structure of the complex between human CD8 a a and HLA-A2. Nature 387: 630-634. (with front cover illustration and short title in the front cover page: CD8 comes to grips with MHC). PDF

Gao, G.F. , Zanotto, P.M.A., Holmes, E.C., Reid, H.W. & Gould, E.A., 1997, Molecular variation, evolution and geographical distribution of louping ill virus. Acta Virologica 41: 259-268.

Zanotto, P.M.A., Gould, E.A., Gao, G.F. , Harvey, P.H. &. Holmes, E.C., 1996, Population dynamics of flaviviruses revealed by molecular phylogenies. Proceedings of National Academy of Sciences USA (PNAS) 93: 548-553. PDF

Zanotto, P.M.A., Gao, G.F. , Gritsun, T.S., Marin, S., Jiang, W.R., Venugopal, K., Reid, H.W. & Gould, E.A., 1995, An arbovirus cline across the Northern Hemisphere. Virology 210: 152-159.

Marin, M.S., McKenzie, J., Gao, G.F. , Reid, H.W., Antoniadis, A. & Gould, E.A., 1995, The virus causing encephalomyelitis in sheep in Spain : a new member of the tick-borne encephalitis group. Research in Veterinary Science 58: 11-13.

Gao, G.F. , Hussain, M.H., Reid, H.W. & Gould, E.A., 1994, Identification of naturally occurring monoclonal antibody escape variants of louping ill virus. Journal of General Virology 75: 609-614.

Gao, G.F. , Hussain, M.H, Reid, H.W. & Gould, E.A., 1993, Classification of a new member of the TBE flavivirus subgroup by its immunological, pathogenetic and molecular characteristics: identification of subgroup-specific pentapeptides. Virus Research 30: 129-144.

Gao, G.F. , Jiang, W.R., Hussain, M.H., Venugopal, K., Gritsun, T.S., Reid, H.W. & Gould, E.A., 1993, Sequencing and antigenic studies of a Norwegian virus isolated from encephalomyelitic sheep confirm the existence of louping ill virus outside Great Britain and Ireland. Journal of General Virology 74: 109-114.

★★此人目前已卸任微生物所所长。

高 福 1955年10月生,内蒙古和林格尔人,初中文化,中共党员,内蒙古和林县大红城乡小缸房行政村-党支部书记,内蒙古和林县第十一届人大代表。自担任小阿房行政村党支部书记以来,带领8个自然村129户831口人早日致富,解决200口人450头(只)家畜饮水,兴建扬水站工程3处,新增水浇地面积300亩,新打导并70眼,实施了“112”工程,牧业上狠抓牲畜“四良四改”及畜禽疫病防治工作,牲畜总头数由1995年的1530头(只)增加到现在3100头(只);生态方面采取大会战集中搞与专业队常年搞的形式共修等高田5000亩,水平为10000延长米,鱼鳞坑3万个,栽植果树150亩,否树700亩,解决831口人的照明问题。在党性原则上,与党中央保持高度一致,高举邓小平理论的伟大旗帜,认真贯彻执行党的各项路线、方针、政策,积极主动完成上级交办的各项任务。

 
 
免责声明:本文为网络用户发布,其观点仅代表作者个人观点,与本站无关,本站仅提供信息存储服务。文中陈述内容未经本站证实,其真实性、完整性、及时性本站不作任何保证或承诺,请读者仅作参考,并请自行核实相关内容。
如何用java替换看不见的字符比如零宽空格​十六进制U+200B
 干货   2023-09-10
网页字号不能单数吗,网页字体大小为什么一般都是偶数
 干货   2023-09-06
java.lang.ArrayIndexOutOfBoundsException: 4096
 干货   2023-09-06
Noto Sans CJK SC字体下载地址
 干货   2023-08-30
window.navigator和navigator的区别是什么?
 干货   2023-08-23
js获取referer、useragent、浏览器语言
 干货   2023-08-23
oscache遇到404时会不会缓存?
 干货   2023-08-23
linux下用rm -rf *删除大量文件太慢怎么解决?
 干货   2023-08-08
刀郎新歌破世界纪录!
 娱乐   2023-08-01
js实现放大缩小页面
 干货   2023-07-31
生成式人工智能服务管理暂行办法
 百态   2023-07-31
英语学习:过去完成时The Past Perfect Tense举例说明
 干货   2023-07-31
Mysql常用sql命令语句整理
 干货   2023-07-30
科学家复活了46000年前的虫子
 探索   2023-07-29
英语学习:过去进行时The Past Continuous Tense举例说明
 干货   2023-07-28
meta name="applicable-device"告知页面适合哪种终端设备:PC端、移动端还是自适应
 干货   2023-07-28
只用css如何实现打字机特效?
 百态   2023-07-15
css怎么实现上下滚动
 干货   2023-06-28
canvas怎么画一个三角形?
 干货   2023-06-28
canvas怎么画一个椭圆形?
 干货   2023-06-28
canvas怎么画一个圆形?
 干货   2023-06-28
canvas怎么画一个正方形?
 干货   2023-06-28
中国河南省郑州市金水区蜘蛛爬虫ip大全
 干货   2023-06-22
javascript简易动态时间代码
 干货   2023-06-20
感谢员工的付出和激励的话怎么说?
 干货   2023-06-18
 
>>返回首页<<
 
 
 
静静地坐在废墟上,四周的荒凉一望无际,忽然觉得,凄凉也很美
© 2005- 王朝网络 版权所有