正向遗传学

正向遗传学(forward genetics)

A classical genetic approach, where one starts with a mutation phenotype and works toward identifing the mutated gene.

研究突变表型以确定突变基因的传统遗传学方法。

One of the first tools available to molecular geneticists is the forward genetic screen. The aim of this technique is to identify mutations that produce a certain phenotype. A mutagen is very often used to accelerate this process. Once mutants have been isolated, the mutated gene can be molecularly identified.

正向遗传学筛查是分子遗传学家最初可使用的一种方法，该技术意在检定产生特定表型的变异。为了提高变异的速度，常使用诱变剂来实现。而一旦分离出变异体，就可以鉴定出对应的突变基因。