卜宪章

卜宪章,1970年8月生,副教授,1994年及1997年分别获得武汉大学学士及硕士学位, 2000年7月获中山大学生物有机化学博士学位。2000-2003年在香港科技大学化学系及生物技术研究所进行组合化学及多肽药物的基础研究及开发工作。2003年11月到中山大学药学院药物化学研究所从事组合化学、多肽药物化学和生物有机化学研究和教学。发表论文30多篇,其中20多篇被SCI收录。
研究兴趣:
1.生物活性多肽及小分子蛋白的设计、合成及构效关系研究。
2.生物活性多肽及以天然活性产物结构为模板的有机小分子的组合化学库的构建及药理活性筛选。
3.以1.2.为基础的抗病毒,抗肿瘤等相关药物研究。
主持项目:
1.抑制CXCR4的SDF-1a重组多肽库的构建及其生理意义,教育部重点科技项目,2005年
2.基质细胞衍生因子衍生多肽的抗肿瘤转移作用研究,广东省自然科学基金,2006
3.还原型谷胱甘肽的化学合成工艺研究,广州白云山天心药业有限公司,2005
4.中山大学医学科学处主任基金,2005年
5.中山大学百人计划引进人才“行动计划”基金,2003年
6.免疫活性多肽的合成研究,横向合作项目,2004年
代表性成果:
论文:
1.Shen YD, Bu XZ*, et al. Novel synthesis of o-naphthothiophenequinone derivatives via regioselective Diels-Alder reaction TETRAHEDRON 61 (38): 9097-9101 SEP 19 2005
2.Shen YD, Bu XZ*, et al. Unexpected synthesis of 2,2 -[1-(4-methoxyphenoxy)propane-2, 2-diyl]bis(5-methoxy-3-methylbenzofuran) CHINESE CHEMICAL LETTERS 16 (12): 1581-1583 DEC 2005
3.LX Pei, SL Huang, YD Shen, LQ An, ZS Huang, YM Li, LQ Gu, XZ Bu*, and Albert S. C.C. Synthesis of novel dihydrofuro-pyridinone derivatives: oxidation coupling of 3-hydroxy-4(1H)-pyridinone with b-dicarbonyl compounds TETRAHEDRON LETTERS 46 (30): 5085-5088 25 July 2005
4.Bu XZ, Wu XM, Ng NLJ, et al. Synthesis of gramicidin S and its analogues via an on-resin macrolactamization assisted by a predisposed conformation of the linear precursors JOURNAL OF ORGANIC CHEMISTRY 69 (8): 2681-2685 APR 16 2004
5.Bu XZ, Wu XM, Xie GY, et al. Synthesis of tyrocidine A and its analogues by spontaneous cyclization in aqueous solution ORGANIC LETTERS 4 (17): 2893-2895 AUG 22 2002
6.Bu XZ, Xie GY, Law CW, et al. An improved deblocking agent for direct Fmoc solid-phase synthesis of peptide thioesters TETRAHEDRON LETTERS 43 (13): 2419-2422 MAR 25 2002
7.Bu XZ, Huang ZS, Zhang M, et al. Synthesis of new 1,1-dimethyl-1,2,3,4- tetrahydrophenanthrene derivatives, TETRAHEDRON LETTERS 42 (33): 5737-5740 AUG 13 2001
8.Shen YD, Wu HQ, Bu XZ*, et al. 2-Amino-7-chloro-1,8-naphthyridine, ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE 60: O1641-O1642 Part 9 SEP 2004
9.Qin CG, Bu XZ, Zhong XF, et al. Optimization of antibacterial cyclic decapeptides JOURNAL OF COMBINATORIAL CHEMISTRY 6 (3): 398-406 MAY-JUN 2004
10.Qin CG, Bu XZ, Wu XM, et al. A chemical approach to generate molecular diversity based on the scaffold of cyclic decapeptide antibiotic tyrocidine A JOURNAL OF COMBINATORIAL CHEMISTRY 5 (4): 353-355 JUL-AUG 2003
11.Wu XM, Bu XZ, Wong KM, et al. Biomimetic synthesis of gramicidin S and analogues by enzymatic cyclization of linear precursors on solid support ORGANIC LETTERS 5 (10): 1749-1752 MAY 15 2003
12.An LK, Bu XZ, Wu HQ, et al. Reaction of tanshinones with biogenic amine metabolites in vitro TETRAHEDRON 58 (52): 10315-10321 DEC 23 2002
13.Qin CG, Zhong XF, Bu XZ, et al. Dissociation of antibacterial and hemolytic activities of an amphipathic peptide antibiotic JOURNAL OF MEDICINAL CHEMISTRY 46 (23): 4830-4833 NOV 6 2003
发明专利:
1.一种合成多肽及其应用,申请号: 200410077777.4, 申请日期2004.12.30;第一发明人
2.一种化合物莱克多巴胺的制备方法,申请号: 200410077776.X,申请日期:2004.12.30;第一发明人
3.Gu LQ*, Bu Xianzhang et al. Cryptotanshionone For Preventing and Alleviating Altheimer’s Disease , PCT, WO 02/60435 A1, PCT/CN01/01497.
4.Gu LQ*, Bu Xianzhang et al. Dihydrofunan Cyclic Tanshionones Used in Treating Hyperammonia and Hepatic Encephalop,PCT,WO 02/55070 A1.