陈晔光

陈晔光 博士

教授、博士生导师

长江特聘教授

1979-1983，就读于江西大学生物系，获生物学学士学位。

1983-1986，就读于江西大学生物系，获动物学硕士学位。

1988-1990，就读于Fordham University，获细胞生物学硕士学位。

1991-1996，就读于美国Albert Einstein College of Medicine，获Ph.D.学位。

1996-2000, Post-doctoral Research Associate, Memorial Sloan-Kettering Cancer Center/Howard Hughes Medical Institute.

2000-2002, Assistant Professor, University of California, Riverside.

2002-至今，清华大学教授。

主要科研领域与方向：

■ 细胞信号转导：利用分子生物学、生物化学及细胞生物学等多学科技术手段研究TGF-β受体的调控、TGF-β和Wnt在肿瘤形成及血管形成中的作用。

Selected Publications:

■ Ma J, Wang Q, Fei T, Han JD, Chen YG# 2007 MCP-1 mediates TGF-β-induced angiogenesis by stimulating vascular smooth muscle cell migration. Blood, 109:987-994.

■ Chen YG#, Wang Z, Ma J, Zhang L, Lu Z 2007 Endofin, a FYVE domain protein, interacts with Smad4 and facilitates TGF-β signaling. Journal of Biological Chemistry, 282:9688-9695.

■ Huang W, Chang HY, Fei T, Wu H, Chen YG# 2007 GSK3β mediates suppression of cyclin D2 expression by tumor suppressor PTEN. Oncogene, 26:2471-2482.

■ Gu Y, Jin P, Zhang L, Zhao X, Gao X, Ning Y, Meng A, Chen YG# 2006 Functional analysis of mutations in the kinase domain of the TGF-β receptor ALK1 reveals different mechanisms for induction of hereditary hemorrhagic telangiectasia. Blood, 107:1951-1954.

■ Zhang L, Gao X, Wen J, Ning Y, Chen YG# 2006 Dapper 1 antagonizes Wnt signaling by promoting Dishevelled degradation. Journal of Biological Chemistry, 381:8607–8612.

■ Zhang, L., Zhou, H., Su, Y., Sun, S., Zhang, H., Zhang, L., Zhang, Y., Ning, Y., Chen, YG# and Meng, A# 2004 Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of Nodal receptors. Science, 306:114-117

■ Lu, Z., Murray, J. T., Luo, W., Li, H., Wu, X., Xu, H., Backer, J. M. and Chen, Y.G# 2002 Transforming growth factor-β activates Smad2 in the absence of receptor endocytosis. Journal of Biological Chemistry, 277:29363-29368.

■ Wu G*, Chen YG*, Ozdamar B, Gyuricza C, Chong PA, Wrana JL, Massagué J, Shi Y. 2000 Structural basis of Smad2 recognition by the Smad Anchor for Receptor Activation. Science. 287:92-97.

■ Massagué, J. and Chen, YG 2000 Controlling TGF-β signaling. Genes & Development, 14:627-644. (Review)

■ Onichtchouk, D*, Chen, YG*, Dosch, R., Gawantka, V., Delius, H., Massagué, J. and Nierhs, C. 1999 Silencing of TGF-β signaling by the pseudoreceptor BAMBI. Nature, 401:480-485.

■ Chen, YG, Hata, A, Lo, R.S., Wotton, D., Shi, Y., Pavletich, N.P. and Massagué, J. 1998 Determinants of specificity in TGF-β signal transduction. Genes & Development, 12:2144-2152.

■ Chen, YG, Liu, F. and Massagué, J. 1997 Mechanism of TGF-β receptor inhibition by FKBP12. EMBO Journal, 16:3866-3876.